ANTIVIRALS FOR H1N1 INFECTION
Antiviral Drugs: Summary of Side Effects
Amantadine and Rimantadine
Among some healthy adults and children, side effects can include central nervous system (CNS) side effects such as nervousness, anxiety, difficulty concentrating, and lightheadedness, and gastrointestinal side effects like nausea and loss of appetite. CNS side effects happen more often among persons taking amantadine than among persons taking rimantadine. Among some other persons with long-term illnesses, more serious side effects, such as delirium, hallucinations, agitation, and seizures, can occur. Side effects usually diminish and disappear after 1 week.
This drug is inhaled and can cause side effects, especially in those with asthma or other chronic lung disease. Decreased respiratory function and bronchospasm have been reported with use of zanamivir. Zanamivir is generally not recommended for use in persons with underlying lung disease such as asthma and chronic obstructive pulmonary disease. Other side effects reported by less than 5% of those who have used this drug are diarrhea, nausea, sinusitis, nasal infections, bronchitis, cough, headache, and dizziness.
The side effects reported most often in those people who took this drug were gastrointestinal (i.e., nausea and vomiting). Nausea and vomiting may be less severe if oseltamivir is taken with food.
Note: On November 13, 2006, FDA approved a labeling supplement
for Roche Laboratories’ Tamiflu (Oseltamivir
Phosphate) to include a precaution about neuropsychiatric
events. The revision is based on postmarketing
reports (mostly from
Visit http://www.fda.gov/medwatch/safety/2006/safety06.htm#tamiflu for more information.